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A large proportion of youth with disruptive behavior disorders is being treated by mental health professionals. A retrospective chart review was performed on a sample of patients with disruptive behavior disorders that included all patients from a teaching hospital psychiatry service between July 1998 and July 2000. Patients were between 6 and 17 years old and had a primary diagnosis of disruptive behavior disorder. About two-thirds of the patients were prescribed multiple medications. Antipsychotic medications were used significantly more often (PMetabolic lysis of tumor cells by neutron irradiation.
The feasibility of neutron irradiation for treatment of tumors has been investigated by studying the effect of mononuclear cells to irradiated LA-N-5 cells. Irradiation of the cells by a fast reactor (UNO, 1.3 MW) at the mid-linear energy range (10-12 MeV) resulted in 13% of total cell killing. A neutron dose of 100 cGy reduced the tumor cell colony forming ability to less than 5%. Irradiation of the cells by thermal neutrons (at 20 and 50 kV) was found to be ineffective at 5 and 50 cGy. The addition of a cytolytic agent such as Triton X-100 at the time of irradiation increased the total cell killing to about 30%. Addition of cytolytic agent at 24 h post-irradiation also enhanced the cell killing. In contrast, the destruction of the cells by the uptake of 3H-deoxyuridine was not enhanced by the addition of Triton X-100. It was therefore concluded that the cells were killed by a direct effect of neutron irradiation rather than by indirect action of the
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